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Avish D. Maru ¹, Rajendra K. Surawase ¹, Prashant V. Bodhe ¹

Affiliations
1 Singhania University, Pacheribari, Dist-Jhunjunu (Raj.) Pin-433515, IN

Abstract

Besides delivering drug to the body, a drug delivery system aims to improve patient compliance, patient acceptance. The dosage forms available for the delivery of topical agents include ointment, paste, lotion, moisturizing cream and powder. However creams are more preferable due to their properties. Present research work is attempted to develop moisturizing creams by using rice bran wax. Rice bran wax is the vegetable wax extracted from rice bran oil. The oil generally contains 2-6 % wax. However it is assumed that on an average it contains 3 % wax. Physicochemical tests such as globule size, evaluation of the intrinsic viscosity and homogeneity of cream products, have been traditionally used to provide reasonable evidence of consistent product performance. However, for the purposes of these studies, the final cream products were characterized by pH, particle size, spreadability, rheological measurement and in vitro occlusivity. All the results match with official specifications.

Keywords

Moisturizing Cream, Rice Bran Wax, Occlusivity.

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Avish D. Maru ¹, Prashant V. Bodhe ¹, Rajendra K. Surawase ¹

Affiliations
1 Loknete Dr. J. D. Pawar College of Pharmacy, A/P-Manur, Tal-Kalwan, Dist-Nasik (M.S.), IN

Abstract

Rice bran wax is a natural vegetable wax and is a value added by-product of Rice bran oil refineries. It is hard nontacky wax and contains higher fatty alcohols and esters which make it comparable to Carnauba wax. In the present work, studies are carried out on Rice bran wax for various physico-chemical properties like solubility, melting point, specific gravity, moisture content, saponification value, acid value, ester value, hydroxyl value, unsaponifiable matter, Iodine number etc. Moreover the solid state compatibility studies was carried out by using mixture of Nifedipine and RBW in the 1:1 ratio at 60°C for 15 days and observed for its physical changes i. e. discoloration, liquefaction, gas formation etc and chemical changes i.e. interaction in between Nifedipine and RBW. It was carried out by using Differential Scanning Colorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FT-IR). The result shows that there are no physical and chemical changes; therefore RBW can be used in formulations of Nifedipine.

Keywords

Rice Bran Wax, Solid State Compatibility Study, Nifedipine.

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Pratiksha Deore ¹, Avish D. Maru ¹, Yashpal M. More ¹

Affiliations
1 Department of Pharmaceutics, Loknete, Dr. J.D. Pawar College of Pharmacy, Manur, Tel – Kalwan - 423501, Dist-Nashik., IN

Abstract

The article mainly focuses on several aspects of orodispersible tablets (ODTs). These types of tablets are those when placed in the mouth cavity disperse the drug in very rapid manner i.e. instantaneously releasing the drug which dissolve in saliva. ODTs are alternative dosage forms for the patients who are suffering from dysphasia i.e. difficulty in swallowing. The oral administration of the drug is most important method for administrating the drugs for systemic effects. Except that the parenteral route is not used routinely for self-administration e.g. insulin. The topical route is only applicable to deliver the drugs into the body for the systemic effect. The administration of the drug by the parenteral route is only beneficial for treating medical emergencies in which the subject is comatose or can’t swallow. Never the less it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route. ODTs are different from traditional tablets in that they are designed to be dispersed on the tongue rather than swallowed whole. ODTs dissolve or disintegrate in the oral cavity without the need of water or chewing. And also it is mainly used for rapid action, to enhance the bioavailability, accurate dosing, enhance palatability, ease of administration, accurate dosing, having good patient compliance because most of the people are familiar with this route. Drugs present in ODTs do not suffer from the first-pass metabolism. This type of drug administration or delivery is becoming popular day by day dueto its numerous advantages.

Keywords

ODT, Superdisintegrants, Dysphagia, Direct compression, Repimelt.

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